Table of Contents

2017 Month : April Volume : 2 Issue : 1 Page : 4-6

THE PREVALENCE AND CIPROFLOXACIN SUSCEPTIBILITY PATTERN OF TYPHOIDAL SALMONELLA IN A TERTIARY CARE HOSPITAL OF NORTH INDIA.

Ashish William1, Aroma Oberoi2, Eshani Dewan3

Corresponding Author:
Dr. Aroma Oberoi,
Professor, Department of Microbiology,
Christian Medical College and Hospital, Ludhiana.
E-mail: draromaoberoi@yahoo.com

ABSTRACT

BACKGROUND

Typhoid fever, also called enteric fever, is an acute, potentially life-threatening febrile illness caused by Salmonella typhi (S. typhi). It is a bacterial infection of the intestinal tract, and the blood stream. S. enterica serovar Paratyphi A, B, or C is estimated to cause 5.5 million cases of enteric fever each year. However, in some regions, notably, south Asia, the proportion of cases of disease due to S. Paratyphi A, B, or C strains is likely much. The emergence of antimicrobial resistance in Salmonella isolates from food potentially compromise the treatment of these infections.

The aim is to study the prevalence and ciprofloxacin susceptibility pattern of typhoidal salmonella in a tertiary care centre hospital of North India.

MATERIALS AND METHODS

In this retrospective study, a total of 733 diagnosed cases of Salmonella patients (550 male and 183 female) with appropriate symptoms were tested in Department of Microbiology, CMC & H, Ludhiana from January 2011 to December 2016.

RESULTS

Out of 733 Salmonella isolates, 594 (81.03%) were Salmonella Typhi and 139 (18.96%) were Salmonella Paratyphi A. There were 732 (99.86%) Nalidixic Acid resistant strains and ciprofloxacin resistant strains using the CLSI 2014 guidelines, which has shown same susceptibility pattern in the past years for CLSI 2011 and CLSI 2012 guidelines.

CONCLUSION

While first-line antimicrobials may still have a role to play in the treatment of enteric fever, ceftriaxone remains the sole defence against ciprofloxacin-resistant Salmonella enterica serotype Typhi and Paratyphi A.

KEYWORDS

Salmonella, Ciprofloxacin, CLSI.

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